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For instance, calibrated intratumoral H 2 O 2 generation, such as through enzyme-based strategies using lactate oxidase or glucose oxidase, can reoxygenate hypoxic tumors, activate dendritic cells, and enhance T-cell infiltration, thereby overcoming immunosuppression and sensitizing tumors to radiotherapy and immune checkpoint inhibitors like anti-PD-1 therapy [237–241]

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Composition of the optimal dual-loaded nanoparticles is presented below in Table 2